Thames Valley Police is appealing for witnesses following a collision on the A4 New Bath Road, Charvil.
At around 8.15am yesterday (11/7), a grey Mini Cooper was involved in a collision with a black Citreon Berlingo van, a silver Vauxhall Astra and a grey BMW.
The driver of the Mini sustained serious injuries and is currently receiving hospital treatment.
The other drivers sustained minor injuries that did not require hospital treatment.
Investigating officer, PC Beth Drummond, of the Roads Policing Unit, based at Three Mile Cross, said: “I am appealing for anyone who may have witnessed this incident to please come forward.
“I would also urge drivers to check their dash-cam footage in case they may have captured the collision or anything that may assist our investigation.
“Anyone with information can contact police on the non-emergency number 101 quoting reference 43190210529 or make a report online.
“Alternatively, you can make a report anonymously to the independent charity Crimestoppers on 0800 555 111.”